Matisse™ Reprogramming System

Progenitor’s original technology, licensed from the University of Utah, MatisseTM Episomal reprogramming system combines all the Yamanaka factors into a single vector for simple and reliable cellular reprogramming into Induced Pluripotent Stem Cells (iPSCs). The generation of MatisseTM iPSCs as a source material has been critical for the development of Progenitor’s cell constructs. The MatisseTM iPSC are beneficial to workflows because of their isogenic and well-characterized composition, resulting in a highly controlled and robust source of cells for Progenitor’s gene editing workflow.

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Degas™ Receiver Cell Engineering

DegasTM Receiver Cell Engineering constructs utilize non-viral genetic modification of the AAVS1 safe harbor loci to introduce a targeted receiver sequence for single step and efficient down-stream modifications. DegasTM technology allows for the development of isogenic cell lines simplifying cellular engineering, enabling insertion of multiple genetic elements to be developed and screened efficiently and reliably. Progenitor’s DegasTM receiver cell technology significantly reduces cellular editing workflows while ensuring quality modified cellular outcomes.

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Degas™ Stealth Immune-Compatible Cell Systems

DegasTM Stealth technology is a non-viral targeted vector, which disrupts the function of MHC-I while also inducing the DegasTM Receiver Cassette. DegasTM Stealth allows for the generation of immune compatible cell lines, enabling off-the-shelf therapies currently lacking in immunotherapy development. DegasTM Stealth cells can be used in tandem with Progenitor’s MonetTM functionalized cell systems to create and enable tools for development of next generation immunotherapy constructs and workflows.

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Monet™ Functionalized Cell Systems

Progenitor’s MonetTM technology utilizes DegasTM modified isogenic cell lines to introduce genetic elements of interest such as CARs, FcRs, suicide genes and co-stimulatory factors in a single transfection. MonetTM technology coupled with DegasTM receiver allows for precise gene insertion and enables multiplexed genetic modifications. The MonetTM and DegasTM technologies allow for gene editing quality and efficiency superior to current cellular engineering approaches.

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Van Gogh™ Footprint-Free Gene Editing

Progenitor’s Van GoghTM technology improves nuclease-based genetic engineering of immune cells by developing an efficient approach for removing unwanted selection cassette DNA. Van GoghTM is a novel ‘self-excising’ cassette that enables rapid, permanent removal of the selection cassette by brief treatment of cells with a small molecule that induces Cre/loxP-mediated DNA recombination without possible reinsertion of deleted elements found in current market techniques. This technology ensures new levels of safety in constructs for cell immunotherapy.

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Dali™ Xenobiotic Ligand-Regulated Genetic Engineering

Progenitor’s DaliTM technology consists of several xenobiotic ligands, which activate self-excising cassettes when co-cultured with modified cell lines. The DaliTM small xenobiotic ligands enable Van GoghTM footprint free gene editing without inducing negative effects on the modified cell lines found to occur with current methods and produce new approaches for next generation cellular immunotherapy.

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Cezanne™ Integrated Cell/Antibody Therapeutic Systems

CezanneTM couples current monoclonal antibody therapeutics with the emerging cell therapy technologies by introducing engineered antibodies that specifically and uniquely pair with MonetTM modified cell lines eliminating innate molecule competition and reducing dose requirements. Progenitor’s revolutionary CezanneTM technology allows cellular therapies to more efficiently target solid tumors, as well as, hematological malignancies.

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